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KMID : 1001020160140020063
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Korean Journal of Urological Oncology
2016 Volume.14 No. 2 p.63 ~ p.68
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Analysis of NF-κB and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma
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Lee Young
Choi Jeong-Hyouk
Lee Dong-Gi
Yoo Koo-Han
Min Gyeong-Eun
Lee Hyung-Lae
Won Kyu-Yeoun
Lim Sung-Jig
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Abstract
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Purpose: A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma(RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival.
Materials and Methods: Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels.
Results: Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage(p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels(p=0.573).
Conclusions: The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival. (Korean J Urol Oncol 2016;14:63-68)
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KEYWORD
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κB, Renal cell carcinoma, Prognosis, Immunohistochemistry
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